Aktuelle Publikationen

This paper uses facts about case allomorphy and possessive morphology in Balkar, a Turkic language spoken in southern Russia, to contribute to the examination of the internal structure of case. A number of recent findings in morpho-syntactic research indicate that case markers have a richer internal structure than their surface appearance typically suggests. Specifically, many works in this vein argue based on cross-linguistic facts about phenomena such as suppletion and syncretism that case features are organized into an implicational containment hierarchy. In this hierarchy, accusative case contains the features of the nominative, and the accusative is itself a sub-part of oblique cases. Many arguments for case containment have relied on diagnostics that are less direct than surface-level morpho-syntactic analysis. In this paper, I argue that there is a part of Balkar grammar that shows the containment of accusative case by obliques in a surface-evident way. While such containment is not normally evident in Balkar, I argue that in certain possessed oblique NPs we see an overt expression of the accusative, except when phonological factors interfere. I go on to discuss other related topics about Balkar and the case containment hypothesis more generally.

We present an approach that shows all relevant subspaces of categorical data condensed in a single picture. We model the categorical values of the attributes as co-occurrences with data partitions generated from structured data using pattern mining. We show that these co-occurrences are a-priori allowing us to greatly reduce the search space effectively generating the condensed picture where conventional approaches filter out several subspaces as these are deemed insignificant. The task of identifying interesting subspaces is common but difficult due to exponential search spaces and the curse of dimensionality. One application of such a task might be identifying a cohort of patients defined by attributes such as gender, age, and diabetes type that share a common patient history, which is modeled as event sequences. Filtering the data by these attributes is common but cumbersome and often does not allow a comparison of subspaces. We contribute a powerful multi-dimensional pattern exploration approach (MDPE-approach) agnostic to the structured data type that models multiple attributes and their characteristics as co-occurrences, allowing the user to identify and compare thousands of subspaces of interest in a single picture. In our MDPE-approach, we introduce two methods to dramatically reduce the search space, outputting only the boundaries of the search space in the form of two tables. We implement the MDPE-approach in an interactive visual interface (MDPE-vis) that provides a scalable, pixel-based visualization design allowing the identification, comparison, and sense-making of subspaces in structured data. Our case studies using a gold-standard dataset and external domain experts confirm our approach’s and implementation’s applicability. A third use case sheds light on the scalability of our approach and a user study with 15 participants underlines its usefulness and power.

The ability to precisely regulate the size of a nanogap is essential for establishing high-yield molecular junctions, and it is crucial for the control of optical signals in extreme optics. Although remarkable strategies for the fabrication of nanogaps are proposed, wafer-compatible nanogaps with freely adjustable gap sizes are not yet available. Herein, two approaches for constructing in situ adjustable metal gaps are proposed which allow Ångstrom modulation resolution by employing either a lateral expandable piezoelectric sheet or a stretchable membrane. These in situ adjustable nanogaps are further developed into in-plane molecular break junctions, in which the gaps can be repeatedly closed and opened thousands of times with self-assembled molecules. The conductance of the single 1,4-benzenediamine (BDA) and the BDA molecular dimer is successfully determined using the proposed strategy. The measured conductance agreeing well with the data by employing another well-established scanning tunneling microscopy break junction technique provides insight into the formation of molecule dimer via hydrogen bond at single molecule level. The wafer-compatible nanogaps and in-plane dynamical break-junctions provide a potential approach to fabricate highly compacted devices using a single molecule as a building block and supply a promising in-plane technique to address the dynamical properties of single molecules.

In this paper we argue for a unified semantics for hypothetical conditionals, hcs, e.g. if it rains, we’ll cancel the picnic, and biscuit conditionals, bcs, e.g., if you are hungry, there are biscuits on the sideboard. We side with recent literature in proposing that differences in the interpretation are related to (in)dependence between antecedent and consequent, but we move beyond current accounts in spelling out a characterization of independence that is actually predictive. We further establish a systematic link between if-constructions and discourse structure, providing a dynamic update model that integrates the QUD, and thus the intentional discourse-structure. We argue that in bcs the antecedent sets up the question that is addressed by the consequent, and show that rescuing (Gricean) relevance in face of independence gives rise to implicatures corresponding to the different flavors associated with bcs. Crucially, we argue, this is the same mechanism responsible for our understanding that in the hc above, for example, it is the rain that will cause the cancellation of the picnic. Along the way we notice how the phenomena observed in if-constructions are also replicated in other quantificational structures. Ultimately, there is not much that is biscuit-specific. Their interpretation is the result of a conspiracy among semantics, dynamic update and intentional discourse-structure.

Glucose intake has a modulating effect on autonomic activity at rest, indicating shared central mechanisms in the regulation of glucose homeostasis and autonomic responses. However, it is still unclear how glucose influences vagal and neuronal activity in response to changing environmental demands. To address this question, we studied the effect of glucose consumption on parasympa- thetic, and medial prefrontal reactivity in response to regenerative processes. For this, we invited fasted, healthy adult participants (n = 62, age mean = 23.0 years, SD = 4.05, 69.4% female) to the laboratory. After the consumption of either water or a drink containing glucose, participants were randomly assigned to a soft shoulder massage or a resting control group. Throughout the experi- ment, we simultaneously monitored cardiac vagal activity, indexed by root mean square of suc- cessive differences (RMSSD), and changes in medial prefrontal activation, indexed by changes in O2Hb concentrations, via continuous electrocardiogram (ECG) and functional near-infrared spec- troscopy (fNIRS) recording. In contrast to previous findings, we could not replicate an amplifying effect of glucose consumption on the physiological relaxation response. While we did not find a positive association between changes in medial prefrontal O2Hb concentration and vagal reactivity to the relaxation intervention, findings from our exploratory analysis suggest that higher blood glucose availability is associated with increases in medial prefrontal oxygenation. We discuss the results in the context of the neurovisceral integration theory.

Poly(lactic-co-glycolic acid) (PLGA) particles are a widely used and extensively studied drug delivery system. The favorable properties of PLGA such as good bioavailability, controlled release, and an excellent safety profile due to the biodegradable polymer backbone qualified PLGA particles for approval by the authorities for the application as a drug delivery platform in humas. In recent years, immunotherapy has been established as a potent treatment option for a variety of diseases. However, immunomodulating drugs rely on targeted delivery to specific immune cell subsets and are often rapidly eliminated from the system. Loading of PLGA particles with drugs for immunotherapy can protect the therapeutic compounds from premature degradation, direct the drug delivery to specific tissues or cells, and ensure sustained and controlled drug release. These properties present PLGA particles as an ideal platform for immunotherapy. Here, we review recent advances of particulate PLGA delivery systems in the application for immunotherapy in the fields of allergy, autoimmunity, infectious diseases, and cancer.

dc.title:

dc.contributor.author: Freistühler, Heinrich

Durinskia capensis is a kleptoplastic dinoflagellate species from high intertidal marine rock pools, which can use a variety of diatoms for photosynthesis. However, very few of the diatoms permit indefinite survival of the dinoflagellate and rbcL sequences show that D. capensis isolated from nature contains one of two closely related Nitzschia species as its kleptoplastids. In culture, without a supply of these ‘essential’ Nitzschia cells to replenish the intracellular store of diatom plastids and other organelles, D. capensis eventually loses all its kleptoplastids and dies. Inside Durinskia, diatoms do not possess frustules and so cannot be compared morphologically with free-living forms. Recently, one of the essential Nitzschia species was isolated from the type locality of D. capensis and grown in culture, allowing comparison with similar Nitzschia species, particularly N. agnita and N. kuetzingioides, examined from type material. We conclude that the ‘essential diatom’ of D. capensis differs morphologically from these and other Nitzschia species and it is therefore described as N. captiva sp. nov. Nitzschia agnita and N. kuetzingioides, on the other hand, are conspecific and N. agnita has priority. Nitzschia captiva and N. agnita are extremely similar in valve shape, dimensions, pattern and ultrastructure, but can be separated by their girdle structure. Nitzschia agnita appears to be a freshwater species, though somewhat salt-tolerant. In contrast, N. captiva, which is known principally from records of the kleptoplastids of D. capensis rather than from frustules, is so far marine.

We report a novel polyester material generated from readily available biobased 1,18-octadecanedicarboxylic acid and ethylene glycol possesses a polyethylene-like solid-state structure and also tensile properties similar to high density polyethylene (HDPE). Despite its crystallinity, high melting point (T_m=96 °C) and hydrophobic nature, polyester-2,18 is subject to rapid and complete hydrolytic degradation in in vitro assays with isolated naturally occurring enzymes. Under industrial composting conditions (ISO standard 14855-1) the material is biodegraded with mineralization above 95 % within two months. Reference studies with polyester-18,18 (T_m=99 °C) reveal a strong impact of the nature of the diol repeating unit on degradation rates, possibly related to the density of ester groups in the amorphous phase. Depolymerization by methanolysis indicates suitability for closed-loop recycling.

Der Markt ist ein zentraler Begriff des Kartellrechts. Er konkretisiert das wettbewerbliche Umfeld in sachlicher, räumlicher und zeitlicher Perspektive. Die Abgrenzung relevanter Märkte ist erforderlich, um Marktanteile – den wohl wichtigsten Indikator für Marktmacht – zu bestimmen. Der Beitrag stellt die herkömmlichen Methoden zur Marktabgrenzung dar und hebt Herausforderungen hervor, auf die ihre Anwendung im Kontext neuer Geschäftsmodelle der Digitalökonomie stößt.

Biological invasions have become a worldwide problem, and measures to efficiently prevent and control invasions are still in development. Like many other parts of the world, China is undergoing a dramatic increase in plant invasions. Most of the currently 933 established (i.e., naturalized) plant species, of which 214 are categorized as invasive, have been introduced into China for cultivation. It is likely that many of those species are still being traded, particularly online, by plant nurseries. However, studies assessing whether naturalized and invasive species are currently being traded more or less than nonnaturalized aliens are rare. We extracted online-trade information for 13,718 cultivated alien plant taxa on 1688.com, the largest website for domestic B2B in China. We analyzed how the presence in online-nursery catalogs, the number of online nurseries that offerred the species for sale, and the product type (i.e., seeds, live plants and vegetative organs) differed among nonnaturalized, naturalized noninvasive, and invasive species. Compared to nonnaturalized taxa, naturalized noninvasive and invasive taxa were 3.7–5.2 times more likely to be available for purchase. Naturalized noninvasive and invasive taxa were more frequently offered as seeds by online nurseries, whereas nonnaturalized taxa were more frequently offered as live plants. Based on these findings, we propose that, to reduce the further spread of invasive and potentially invasive plants, implementation of plant-trade regulations and a monitoring system of the online horticultural supply chain will be essential.